Journal of The Egyptian Society of Nephrology and Transplantation

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 18  |  Issue : 1  |  Page : 17--23

Fibroblast growth factor-23 and vascular calcification in chronic kidney disease and hemodialysis patients


Sherif A Zaki1, Iman E El Gohary1, Eman M Elsharkawy2, Doaa I Hashad3, Doaa M Emara4, Marwa R.A El Hameed1 
1 Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Cardiology and Angiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
3 Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
4 Department of Radiodiagnosis and Intervention, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Correspondence Address:
Dr. Marwa R.A El Hameed
Master of Internal Medicine, Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria
Egypt

Context Fibroblast growth factor-23 (FGF-23) is secreted by osteoblasts and regulates phosphate and vitamin D homeostasis. As a potential explanatory mechanism of FGF-23-associated mortality, multiple studies have consistently demonstrated that higher FGF-23 levels are independently associated with greater risk of prevalent and incident left ventricular hypertrophy (LVH). In contrast, observational studies reported conflicting results on the association of FGF-23 with arterial calcification, which is another prominent pattern of cardiovascular injury in chronic kidney disease (CKD). Aims The aim was to correlate between serum FGF-23 and vascular calcification (VC) in CKD and hemodialysis (HD) patients. Settings and design A single-center cross-sectional study was conducted on 60 patients who were divided into two groups. Group I included thirty patients with CKD stages 4 and 5, and group II included thirty patients on maintenance HD. Group III included 30 age-matched and sex-matched healthy volunteers. Materials and methods Estimation of serum calcium, phosphorus, bone-specific alkaline phosphatase, intact parathyroid hormone, and serum FGF-23 level was carried out. Assessment of LVH by echocardiography and VC by multidetector computed tomography was done. Results There was a statistically significant negative correlation between FGF-23 and serum calcium level in group I and of no statistical significant correlation in group II and III, whereas there were a statistically significant positive correlations between FGF-23 with serum phosphorus, bone-specific alkaline phosphatase and intact parathyroid hormone in groups I and II and of no statistical significant correlations in group III. There were statistically significant positive correlations between FGF-23 and both left ventricular mass index and VC in groups I and II (P<0.001) and of no statistical significant correlation in group III. Conclusion FGF-23 correlates with LVH and VC in CKD and HD patients.


How to cite this article:
Zaki SA, El Gohary IE, Elsharkawy EM, Hashad DI, Emara DM, El Hameed MR. Fibroblast growth factor-23 and vascular calcification in chronic kidney disease and hemodialysis patients.J Egypt Soc Nephrol Transplant 2018;18:17-23


How to cite this URL:
Zaki SA, El Gohary IE, Elsharkawy EM, Hashad DI, Emara DM, El Hameed MR. Fibroblast growth factor-23 and vascular calcification in chronic kidney disease and hemodialysis patients. J Egypt Soc Nephrol Transplant [serial online] 2018 [cited 2018 Oct 19 ];18:17-23
Available from: http://www.jesnt.eg.net/article.asp?issn=1110-9165;year=2018;volume=18;issue=1;spage=17;epage=23;aulast=Zaki;type=0