Journal of The Egyptian Society of Nephrology and Transplantation

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 18  |  Issue : 1  |  Page : 11--16

Procalcitonin as an inflammatory marker in comparison between high-flux and low-flux hemodialysis in patients with end-stage renal disease


Hesham M El Sayed, Hussein S Hussein, Sabah A Hammad 
 Department of Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Prof. Hesham M El Sayed
Prof. of Internal Medicine and Nephrology Nephrology Department, Faculty of Medicine, Ain Shams University, Cairo
Egypt

Background Although procalcitonin (PCT) has been described as a new marker of infection and inflammation, it has not been extensively studied in hemodialysis (HD) patients. Patients and methods We measured PCT serum levels and high-sensitivity C-reactive protein (hs-CRP) before and immediately after HD in 50 adult HD patients (25 treated with high-flux membranes and 25 with low-flux membranes), without history of concurrent infections. Results The baseline PCT levels before HD were higher than healthy individuals. There was a highly significant decrease in PCT serum levels after HD session in patients undergoing HD by high-flux membranes but not by low-flux membranes (high flux 0.54 ng/ml pre-HD vs. 0.26 ng/ml post-HD, P=0.001, whereas in low flux 0.50 ng/ml vs. 0.53 ng/ml, P=0.066). Hs-CRP levels were unchanged in both groups. There was no correlation between PCT and CRP. Conclusion Although PCT is considered a sensitive and specific diagnostic and prognostic marker of systemic bacterial infection, we suggest that specific reference ranges might be developed in patients with impaired renal function; moreover, its clinical usefulness might be limited in patients undergoing HD with high-flux membranes.


How to cite this article:
El Sayed HM, Hussein HS, Hammad SA. Procalcitonin as an inflammatory marker in comparison between high-flux and low-flux hemodialysis in patients with end-stage renal disease.J Egypt Soc Nephrol Transplant 2018;18:11-16


How to cite this URL:
El Sayed HM, Hussein HS, Hammad SA. Procalcitonin as an inflammatory marker in comparison between high-flux and low-flux hemodialysis in patients with end-stage renal disease. J Egypt Soc Nephrol Transplant [serial online] 2018 [cited 2018 Sep 24 ];18:11-16
Available from: http://www.jesnt.eg.net/article.asp?issn=1110-9165;year=2018;volume=18;issue=1;spage=11;epage=16;aulast=El;type=0