• Users Online: 390
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLES
Year : 2019  |  Volume : 19  |  Issue : 4  |  Page : 101-108

Urinary neutrophil gelatinase-associated lipocalin as a clinical biomarker in patients with diabetic nephropathy in Beni-Suef Governorate, Egypt


1 Internal Medicine Department, Faculty of Medicine, Beni Suef University, Egypt
2 Clinical Pathology Department, Faculty of Medicine, Beni Suef University, Egypt
3 Internal Medicine Unit, Health Radiation Research Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Egypt

Correspondence Address:
PhD Mohamed S Tawfik
3 Ahmed El Zommor Street, Nasr City, Cairo, 12411
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jesnt.jesnt_9_19

Rights and Permissions

Aim To demonstrate the importance of the marker of tubulointerstitial damage, urinary neutrophil gelatinase-associated lipocalin (uNGAL), in the follow-up of the progression of chronic kidney disease in patients with type 2 diabetes mellitus. Patients and methods A total of 60 patients with type 2 diabetes mellitus with various degrees of renal impairment were subdivided into three categories based on urine albumin/creatinine ratio (UACR): 20 patients with normoalbuminuria (<30 mg albumin/g Cr), 20 with microalbuminuria (30–300 mg albumin/g Cr), and 20 with macroalbuminuria (>300 mg albumin/g Cr). Few exclusion criteria were considered such as infections, neoplasia, and any inflammation that could interfere with uNGAL measurement. Twenty healthy individuals were taken as a control group. Serum creatinine, UACR, urine protein, and estimated glomerular filtration rate (eGFR) are measured to determine their correlation with uNGAL, which was measured using a suitable human NGAL ELISA kit. The Modification of Diet in Renal Disease formula was used to calculate the eGFR in patients. Results The differences between the means of uNGAL in the different patients’ groups were found to be highly statistically significant (P<0.05). There was a significant negative relationship (inverse correlation) between uNGAL levels and eGFR in the three patient groups (P<0.05) and also a converse correlation was noted between uNGAL and UACR in the various patient groups involved in the study (P<0.05). Conclusion NGAL may be useful as a clinical marker to predict and assess the progression of diabetic nephropathy in patients with type 2 diabetes mellitus with nephropathy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed147    
    Printed16    
    Emailed0    
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal