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ORIGINAL ARTICLE
Year : 2019  |  Volume : 19  |  Issue : 3  |  Page : 95-100

Epidemiology of acute kidney injury in malignant and benign haematological disorders. A tertiary center experience


1 Nephrology and Renal Transplantation Unit, Department of Internal Medicine, Assiut University, Assiut, Egypt
2 Department of Internal Medicine, Assiut University, Assiut, Egypt

Correspondence Address:
Phd Nephrology Marwa Kamal A Khairallah
Nephrology and Renal Transplantation Unit, Department of Internal Medicine, Assiut University, Assiut 71515, Arab Republic of Egypt
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jesnt.jesnt_16_19

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Objective Patients with hematological disorders whether benign or malignant are at high risk for acute kidney injury (AKI), which is associated with high morbidity and mortality. We sought to appraise the frequency, predictors, and outcome of AKI in a large cohort study of patients with hematological disorders. Patients and methods A prospective, observational database was undertaken at a tertiary referral hematological and oncological center hospital. We collected the medical data of in-hospital patients with AKI and hematological disorder between July 2016 and September 2018 who met the criteria for RIFLE (risk, injury, and failure; loss; and end-stage kidney disease) classification and were followed up by a nephrologist. Results According to RIFLE criteria, 137 (28.5%) patients had AKI. Overall, 35.8% of patients with hematological disorders and AKI were admitted into the ICU. Moreover, 23.4% of the patients with hematological disorders and AKI died, and only 8.4% of the survivors with AKI received renal replacement therapy. Mortality in patients with AKI in hematological disorders was associated with the presence of malignant hematological diseases (odds ratio: 5.36 and P=0.001), underlying kidney diseases (odds ratio: 1.35 and P=0.001), and occurrence of tumor lysis syndrome (odds ratio: 2.87 and P=0.001). Conclusions AKI in patients with hematological disorders, both benign and malignant disorders, is not uncommon and is associated with increased rates of ICU admission and mortality.


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