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ORIGINAL ARTICLE
Year : 2019  |  Volume : 19  |  Issue : 3  |  Page : 75-79

Cystatin: assessment of renal function in chronic kidney disease and postrenal transplant patients


Department of Internal Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
MD Ahmed Y Ali
MD of Internal Medicine, Giza, 12511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jesnt.jesnt_22_18

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Objectives Cystatin C is an alternative parameter for the assessment of renal function. The objective of the study is to evaluate the efficacy of serum cystatin C as a marker of renal dysfunction among different chronic kidney disease (CKD) and postrenal transplant patients. Patients and methods A total of 60 postrenal transplants patients and 60 patients with CKD were compared with 30-old aged patients regarding serum cystatin and through evaluating cystatin-based estimated glomerular filtration rate (eGFR) and creatinine-based eGFR equations versus measured GFR using 99mTc diethylene-triamine-penta-acetate method. Results Serum cystatin is significantly higher in the CKD group. Cystatin is negatively correlated with measured GFR in all groups, with P value less than 0.01, serum cystatin is a better parameter than serum creatinine to rule out renal dysfunction (sensitivity 95.1 and 80.3%, respectively). Cystatin eGFR (Larsson equation) has less sensitivity and specificity than creatinine eGFR formulae namely modified diet in renal disease and Gault–Cockcroft. Conclusion Serum cystatin C is a useful parameter in recognizing individuals with early renal impairment and can be used as a screening tool with significant performance


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