• Users Online: 272
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 18  |  Issue : 2  |  Page : 34-39

Does brain-derived neurotrophic factor play a role in depression in hemodialysis patients?


1 Department of Internal Medicine and Nephrology, Alexandria University, Egypt
2 Department of Clinical and Chemical Pathology, Alexandria University, Alexandria, Egypt
3 Department of Neuropsychiatry Medicine, Alexandria University, Alexandria, Egypt

Correspondence Address:
Eman M.M Farag
Specialist in the Department of Internal Medicine and Nephrology, Alexandria University Students’ Hospital, Egypt 11 Ibn Elkady Street, Victoria, El Raml, Alexandria
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jesnt.jesnt_22_17

Rights and Permissions

Background Many end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) suffer from depressive disorders as well as anxiety. These often underdiagnosed conditions not only decrease the quality of life of patients but also increase their mortality. Decrease in brain-derived neurotrophic factor (BDNF) has emerged as a marker of depression that can be used for the diagnosis and follow-up of depression in the general population. Objectives The aim of the present study was to study the role of BDNF in depression in HD patients. Patients and methods A single-center, cross-sectional study was carried out including 50 depressed (group I) and 35 nondepressed (group II) ESRD patients on maintained HD according to the Hospital Anxiety and Depression Scale. BDNF levels were measured in all patients. Result The mean BDNF level was significantly lower in depressed HD patients (2556.0±1498.15 pg/ml) in comparison with group II (9017.14±4249.60 pg/ml), with a P value less than 0.001. Serum BDNF level was also correlated negatively with both the anxiety (rs=−0.440, P<0.001) and the depression score (rs=−0.693, P<0.001) in the total sample. In addition, BDNF was a significant predictor of depression with a high area under the receiver operating characteristics curve (ROC curve) (AUC) (95% confidence interval=0.939–0.998, P<0.001). Conclusion Anxiety and depression are closely linked in ESRD patients. BDNF is significantly lower in depressed HD patients and correlates negatively with both depression and anxiety. It is a useful biomarker in the detection of depression, a common often undiagnosed and undertreated condition, in ESRD.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed543    
    Printed41    
    Emailed0    
    PDF Downloaded51    
    Comments [Add]    

Recommend this journal