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Year : 2017  |  Volume : 17  |  Issue : 2  |  Page : 67-69

Eighteen years on postrenal transplantation, lymphoproliferative disorder, and its implication

1 Department of Nephrology, KIMS, Trivandrum, Kerala, India
2 Department of Respiratory Medicine, KIMS, Trivandrum, India
3 Department of Medical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
4 Department of Pathology, Regional Cancer Centre, Trivandrum, Kerala, India

Correspondence Address:
Arun Kumar Narayanan
# A-3,2nd floor, Manushka Garden, Venpalavattom, Anayara Trivandrum- 695029, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jesnt.jesnt_1_17

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Post-transplant lymphoproliferative disorder (PTLD) represents a life-threatening disorder occurring after transplantation, ranging from a polyclonal mononucleosis-like illness to a monomorphic high-grade neoplasm with cytologic and histopathologic evidence indicative of transformation to lymphoma. PTLD of diffuse large B-cell lymphoma subtype isolated to the lungs is a rare diagnosis. We describe here a case of an immunocompromised adult diagnosed with diffuse large B-cell lymphoma PTLD limited to his lung with an associated mass and locoregional lymphadenopathy on imaging. Even more unique to our case was the absence of underlying cytomegalovirus and Epstein–Barr virus infection. In the post-transplant setting, immunocompromised state or Epstein–Barr virus-positive state has risk for PTLD. A live-related donor kidney transplant recipient, donor being the father, presented with cough, expectoration, and fever, which were not responding to sequential antibiotics. Evaluation showed large B-cell lymphoma of the lung after 18 years of transplant, which has not been reported before for its occurrence so late after renal transplantation.

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