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 Table of Contents  
LETTER TO THE EDITOR
Year : 2017  |  Volume : 17  |  Issue : 1  |  Page : 42

Use of proton-pump inhibitors and risk of kidney failure: an alarming sign!


Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangalore, India

Date of Submission29-Sep-2016
Date of Acceptance05-Apr-2017
Date of Web Publication13-Jun-2017

Correspondence Address:
Uday V Mateti
Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangalore
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jesnt.jesnt_26_16

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How to cite this article:
Mateti UV. Use of proton-pump inhibitors and risk of kidney failure: an alarming sign!. J Egypt Soc Nephrol Transplant 2017;17:42

How to cite this URL:
Mateti UV. Use of proton-pump inhibitors and risk of kidney failure: an alarming sign!. J Egypt Soc Nephrol Transplant [serial online] 2017 [cited 2017 Aug 16];17:42. Available from: http://www.jesnt.eg.net/text.asp?2017/17/1/42/207901

Proton-pump inhibitors (PPIs) are widely used prescription medications globally and are promoted as safe and accessible (without prescription) over the counter. These are commonly prescribed for the management of dyspepsia, peptic ulcers, Helicobacter pylori infection, and hospital-induced stress [1]. Numerous studies have stated that extensive use of PPIs is outside the contemporary recommending guidelines. Numerous observational studies on the use of PPIs have reported unusual adverse drug reactions (ADRs) including hip fracture, community-acquired pneumonia, acute interstitial nephritis, and acute kidney injury [2],[3],[4]. It is presumable that use of PPIs could also be a risk factor for chronic renal failure (CRF), potentially arbitrated by persistent acute kidney injury [1],[2]. Nevertheless, growing evidence reveals that PPIs are associated with a number of ADRs and are overprescribed. The use of PPIs and risk of kidney injury reported by different studies are summarized in [Table 1]. It is time to investigate the relationship between CRF and PPI usage. The problem with previously conducted studies is that patients take more than one medication, and therefore the exact role of PPIs and their impact on the incidence of CRF is hard to determine. It requires extensive follow-up of patients and suitable controls.
Table 1 Evidences for the use of PPIs and the risk of kidney injury

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Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.[5]

 
  References Top

1.
Lazarus B, Chen Y, Wilson FP, Sang Y, Chang AR, Coresh J et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med 2016; 176:238–246.  Back to cited text no. 1
    
2.
Xie Y, Bowe B, Li T, Xian H, Balasubramanian S, Al-Aly Z et al. Proton pump inhibitors and risk of incident CKD and progression to ESRD. J Am Soc Nephrol 2016; 27:3153–3163.  Back to cited text no. 2
    
3.
Antoniou T, Macdonald EM, Hollands S, Gomes T, Mamdani MM, Garg AX et al. Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study. CMAJ Open 2015; 3:E166–E171.  Back to cited text no. 3
    
4.
Sampathkumar K, Ramalingam R, Prabakar A, Abraham A. Acute interstitial nephritis due to proton pump inhibitors. Indian J Nephrol 2013; 23:304–307.  Back to cited text no. 4
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5.
Klepser DG, Collier DS, Cochran GL, Klepser DG, Collier DS, Cochran GL. Proton pump inhibitors and acute kidney injury: a nested case-control study. BMC Nephrol. 2013; 14:150.  Back to cited text no. 5
    



 
 
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